Published 30th March 2017

Inivata and Gustave Roussy Publish Positive Results from Prospective Clinical Study

Portfolio company Inivata, a global clinical cancer genomics company employing a revolutionary approach to circulating tumor DNA (ctDNA) analysis to improve personalized healthcare in oncology, and Gustave Roussy, a premier European Cancer Centre, today announce the publication in the journal Annals of Oncology of positive results from a study using the InVisionTM liquid biopsy platform to guide cancer treatment.

The study, led by Benjamin Besse—Chairman of the Thoracic Unit, Medical Oncologist at Gustave Roussy—is the first to be published using ctDNA results to test the efficacy of cancer treatment in a real-world setting.

Forty-eight patients with advanced non-small cell lung cancer (NSCLC), who had been shown to have a common epidermal growth factor receptor EGFR mutation at an initial biopsy, and had developed tyrosine kinase inhibitor (TKI) resistance, were tested using Inivita’s InVisionTM ctDNA liquid biopsy platform for the presence of T790 mutations. The T790 mutation is a known mechanism of acquired resistance to the first and second TKIs used in the treatment of this patient cohort. Importantly, the patients in the study were not able to have a new tissue biopsy at the time of disease progression for reasons including lack of available tissue or the localisation of the tumour. The ctDNA T790M mutational status was detected in 50% of NSCLC patients, which is consistent with detection rates seen in tissue biopsies.

Clive Morris, Chief Medical Officer at Inivata, said:

“This study shows for the first time the clinical utility of our InVisionTM ctDNA liquid biopsy platform in guiding treatment decisions and delivering better patient outcomes. While a relatively small study, the fact that these patients were able to receive targeted therapy despite the unavailability of a tissue biopsy and the close comparability of mutation detection and treatment outcomes to standard practice based on tissue profiling is extremely encouraging. We are proud to have worked closely with Gustave Roussy, a world-renowned cancer centre, on this study. We have an extensive, international clinical validation programme ongoing and look forward to presenting further results as we advance towards commercialisation of our InVisionTM platform.”

Read Inivata's full statement

Read the publication [paid]